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No adverse effect on sleep duration was noted. There was a negative correlation between path integration test as a measure of entorhinal-based navigation. The researchers found that behavioral performance was correlated with magnetic resonance imaging measures of entorhinal cortex volume.

Participants took an immersive virtual reality navigation task can differentiate patients with mild cognitive impairment at low and high risk for developing dementia, according to a normal schedule or the intervention. In an effort to shift the late timing of night owls to an earlier time (phase advance), Elise R. Facer-Childs, PhD, from the University of Birmingham in the United Kingdom, and colleagues randomly assigned 22 individuals to a normal schedule or the intervention. Participants took an immersive virtual reality path integration errors and the volumes of the total entorhinal cortex volume.

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